Donald Trump has suffered the biggest loss of his presidency to date, according to talk show host Jimmy Kimmel.The comedian returned to his late-night show after a week-long absence and said that during his vacation, the president suffered one of the most grueling blows to his term so far after the Supreme Court voted 6-3 against Trump's use of tariffs.Speaking during the opening monologue of his show, Kimmel said, "As just about everyone except him expected, the Supreme Court ruled that the tariffs he is so inexplicably proud of are unconstitutional, the very conservative Supreme Court ruled against him 6-3; this was Donald Trump's most humiliating legal defeat yet."Even more than the one with the porn star, where he farted through the whole trial. Trump was angry, he lashed out at his own campaign justices, he called them fools and lapdogs and said they were an embarrassment to their families, and as father to Eric and Don Jr., that is a man that knows an embarrassment to his family."Kimmel says the loss in the Supreme Court is just the start of trouble for Trump, who must now ease business worries.The talk show host continued, "The whole thing is a mess because these companies want refunds for the tariffs they paid, but no one knows how to go about getting one, and Donald Trump doesn't give refunds."If he gives a refund, it's like when Rumpelstiltskin says his own name. He shrivels up and disappears. So what do you do in a situation like that? You get smacked down very publicly by your own conservative court."Kimmel went on to mock Trump's dwindling approval rating, with the president seeing some of his lowest polling figures to date.He said, "This guy has a weird pathological reflex to jack up the numbers. It's so automatic that even when it's like, a bad number, he jacks it up to a slightly less bad number. '36%? How dare you say 38%, there's no way I'm at 40%.'"